EUH Morning Report: What are extraintestinal manifestations of inflammatory bowel disease (IBD)?

The Bottom Line:

“Extraintestinal manifestations (EIMs) are commonly reported in IBD patients. It has been reported that 6.2% to 46.6% of IBD patients exhibit one or more EIMs either before or after the diagnosis of IBD.” (Ferri, 2021).

Extraintestinal manifestions of ulcerative colitis (UC) and Crohn disease (CD) include:

  • Joint manifestations: Axial arthritis (ankylosing spondylitis [AS] and sacroiliitis [SI]) and peripheral arthropathy
  • Skin manifestations: Pyoderma gangrenosum, erythema nodosum, sweet syndrome, and psoriasis
  • Hepatobiliary manifestation: Primary sclerosing cholangitis (PSC)
  • Ocular manifestations: Uveitis, episcleritis, scleritis, and iritis
  • Vascular manifestation: Thromboembolism

From: Clincial Overview: Inflammatory Bowel Disease, Extraintestinal Manifestations.
Ferri FF (ClinicalKey). Created June 23, 2021.


DynaMed [Internet]. Crohn Disease in Adults – Complications; [updated 2021 May 26, cited 2021 Aug 18]. Registration and login required.

Rogler G, et al. Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. Gastroenterology. 2021 Aug 3:S0016-5085(21)03337-0. Full-text for Emory users.