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Category Archives: EUH
The Bottom Line: Many underlying systemic conditions can cause nephrotic syndrome (NS), although type 2 diabetes mellitus and systemic lupus erythematosus are most common. NS may not present as a primary diagnosis, but instead as one of multiple disease manifestations, … Continue reading
The Bottom Line: A study involving 86,836 participants found the Abbott Architect HIV Ag/Ab Combo Assay to have a 79.8% sensitivity and 99.9% specificity with a positive predictive value of 59% (Peters et al, 2016). Reference: Peters PJ, Westheimer E, … Continue reading
The Bottom Line: Membranoproliferative glomerulonephritis (MPGN) is diagnosed on the basis of a glomerular-injury pattern that is common to a heterogeneous group of diseases. Two major pathophysiological factors — the deposition of immunoglobulin and the deposition of complement in the … Continue reading
The Bottom Line: Plastic bronchitis (PB) is an uncommon pulmonary disease characterized by production of cohesive and branching casts filling the airways. The diagnosis of PB is confirmed by a history of expectoration of branching airways casts, or by removing … Continue reading
The Bottom Line: Up to 1 in 6 admitted syncope patients may have PE – Works out to <4% of ED presenters with loss of consciousness (LOC), and likely <<1% of all syncope cases (which includes patients who do not … Continue reading
EUH Dressler Conference: What is the pathophysiology of disseminated intravascular coagulation (DIC)?
The Bottom Line: DIC is a systemic pathophysiologic process and not a single disease entity. The massive tissue factor stimulus results in excess intravascular thrombin, which overcomes the anticoagulant systems and leads to thrombosis. Because of consumption of coagulation factors … Continue reading
EUH Dressler Conference: Can blood pressure index (BPI) be a predictor of right ventricular dysfunction in PE?
The Bottom Line: A recent study found the ratio of systolic to diastolic blood pressure ≤1.7 to be a strong indicator of right ventricle dysfunction. In his review of the article, Pallin (2017) notes that the results should not change … Continue reading