The Bottom Line: Inflammatory idiopathic myopathies (IIM) are a group of rare autoimmune diseases characterized by proximal skeletal muscle weakness, raised muscle enzymes and extramuscular organ involvement, most frequently the lungs, resulting in interstitial lung disease (ILD). Numerous autoantibodies are … Continue reading
The mechanism of hemorrhagic complication in HSV encephalitis is unclear. The possible mechanisms include small vessel rupture due to vasculitis and transient hypertension caused by increased intracranial pressure. Gyral pattern of the hemorrhage may suggest that the hemorrhagic complication in … Continue reading
Bottom line: Unless there are additional neurologic signs or symptoms, neurologic testing for syncope is rarely helpful. Source Linzer, M, et al. “Diagnosing syncope. Part 1: Value of history, physical examination, and electrocardiography. Clinical Efficacy Assessment Project of the American … Continue reading
Thwaites, Guy E, Ronaldvan Toorn, and JohanSchoeman. “Tuberculous meningitis: more questions, still too few answers.” Lancet neurology 12.10 (2013):999-1010.
Lumbar puncture/Procedure considerations/Neuroimaging in Dynamed The section on Testing to Consider Prior to Performing an LP in DynaMed’s entry for lumbar puncture summarizes two prospective cohort studies and lists clinical findings such as age and aspects of clinical history and … Continue reading
The Bottom Line: One of the important neurologic side-effects attributed to the over-use of NSAIDs is aseptic meningitis. Reference: Auriel et al. Nonsteroidal anti-inflammatory drugs exposure and the central nervous system. Handb Clin Neurol 2014;119:577-84. Summary: CNS effects of NSAID toxicity range … Continue reading
Bottom line: Table 3 from study by the Magnims European research network provides estimated data (95% confidence interval) for sensivity, specificity, accuracy, positive predictive value, positive likelihood ratio, and negative likelihood ratio for old and new McDonald criteria (divided up by overall criteria (dissemination … Continue reading