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Tag Archives: immunology
The Bottom Line: Acute rheumatic fever is no longer a nationally notifiable disease in the United States, and its annual incidence in the continental United States declined in the late 20th century to approximately 0.04–0.06 cases per 1,000 children. Exceptions … Continue reading
VA Resident Report: Is there an increased risk for patients with Terminal Complement Deficiency and HIV?
The Bottom Line: The Advisory Committee on Immunization Practices has previously recommended routine vaccination of persons aged ≥2 months who have certain medical conditions that increase risk for meningococcal disease, including persons who have persistent deficiencies in the complement pathway … Continue reading
EUHM Resident Report: What is the rate of lymphogranuloma venerum developing in the distal rectum and causing painful bleeding?
Anorectal LGV is a common cause of acute proctitis and proctocolitis among HIV-infected MSM who practice unprotected anal sex, and it is frequently associated with other rectal STDs. The implementation of routine screening and prompt diagnosis of these rectal infections … Continue reading
What is the clinical presentation associated with various drugs that incite drug rash with eosinophilia and systemic symptoms (DRESS)?
Bottom line: Typically presents with fever, rash, and solid organ involvement. Commonly associated drugs include aromatic anticonvulsants and sulfonamides. Walsh SA, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. Clin … Continue reading
The Bottom Line: In this first published RCT of vitamin D supplementation in sarcoidosis, it was found that patients with sarcoidosis and 25OHD <50 nmol/L, vitamin D supplements did not alter average serum calcium or urine calcium, but had no benefit on surrogate markers … Continue reading
The Bottom Line: Patients who receive PE are typically older, and have higher complication rates including respiratory failure. Reference: Alshekhlee A, Hussain Z, Sultan B, Katirji B. Immunotherapy for Guillain-Barré syndrome in the US hospitals. J Clin Neuromuscul Dis. 2008 Sep;10(1):4-10. Summary: In this large US cohort, it was discovered that patients … Continue reading
WHAT IS ANCA? In: Neuromuscular Case Studies, 1st ed. [MDConsult]. This table (63-1) summarizes diseases associated with C-anca, P-anca, and X-anca and the antigens MPO (myeloperoxidase), BPI (bactericidal/permeability-increasing), PR3 (proteinase 3), elastase, cathepsin-G, lysosomal and lactoferrin jkn 2/16