Tag Archives: Hematology

VA Resident Report: What is the association between squamous cell carcinoma and acquired factor VIII?

Following surgery for the patient in this case study, the tumor nor the coagulation inhibitor has recurred after 6 months’ follow-up. While it is possible that the inhibitor may have remitted spontaneously or remained in remission because of the therapy … Continue reading

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VA Resident Report: How does B12 deficiency cause pancytopenia?

The Bottom Line: A common etiological factor is nutritional deficiency anemia, especially megaloblastic anemia. It accounted for 40 (19.51%) patients presenting with pancytopenia. Megaloblastic anemia due to vitamin B12 deficiency is well recognizable cause of pancytopenia. Various study reported the … Continue reading

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VA Resident Report: Are there cases in the United States of malaria transmitted via blood transfusions?

The Bottom Line: CDC received 1,925 reported cases of malaria with an onset of symptoms in 2011 among persons in the United States, including 1,920 cases classified as imported, one laboratory-acquired case, one transfusion-related case, two congenital cases, and one … Continue reading

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Review of advancements in treating Multiple Myeloma (MM)

The Bottom Line: New diagnostic criteria, a Revised International Staging System, and the approval of three drugs (four others pending approval) have greatly advanced the treatment, diagnosis, staging, risk-stratification and management of MM. These changes, as well as others detailed … Continue reading

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Administration of hypotonic saline

There are no level II trials examining the use of hypertonic saline in hyponatraemia. One study used a prolonged infusion of 3% HS in seven patients with severe neurological complications from hyponatraemia. Another controlled hyponatraemic seizures with 50 mL of … Continue reading

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What are the mechanisms for coagulopathy and thrombophilia in patients with cirrhosis?

From Cirrhosis and its complications.  In:  Harrison’s Internal Medicine, 18th ed. Under Major Complications, toward the bottom of the page. Explains that patients with cirrhosis experience a decrease in production of clotting factors and diminished clearance of anticoagulants.  Portal hypertension … Continue reading

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Urine sodium levels in hypovolemic and euvolemic patients

“Spot urine sodium and FeNa+ 1. Since hypovolemia promotes avid sodium reabsorption, hypovolemia is usually associated with a low urinary sodium concentration (< 20–30 mEq/L) and low FeNa+(< 0.5%). On the other hand, euvolemic patients do not have a stimulus … Continue reading

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