Do NSAIDs cause acute pancreatitis?

Bottom line: Limited evidence implicates some NSAIDs as uncommon causes of acute pancreatitis.
Summary: Drug-induced pancreatitis is the third most common cause of acute pancreatitis, comprising approximately 5% of all cases (Dig Dis Sci. 2010 Oct;55(10):2977-81). DynaMed’s entry for sulindac lists pancreatitis as an adverse effect and provides Merck’s prescribing information as the source (See Sulindac > Cautions and Adverse Effects > Warnings/Precautions > Major Toxicities. In: DynaMed). Case reports implicate mesalamine (Am J Gastroenterol. 1997 Dec;92(12):2302-303; Korean J Gastroenterol. 2007 Dec;50(6):379-83). Searches of pdr.net implicate sulindac, ketorolac, meloxicam, mefenamic acid, naproxen, piroxicam, nabumetone, diclofenac, ibuprofen, and celecoxib (J Clin Gastroenterol. 2005 Sep;39(8):709-16), and Drugs.com lists pancreatitis as a possible side effect in the entries for the first six medications in the aforementioned list.

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