Tag Archives: GI & liver

EUHM Resident Report: What is the relation of bilirubin levels to jaundice abnormalities?

The Bottom Line: Jaundice occurs when there are disruptions along this metabolic pathway, causing  an increase in unconjugated bilirubin (e.g., from increased red blood cell destruction or impaired bilirubin conjugation) or conjugated bilirubin. Figure 1.  An algorithmic approach to the … Continue reading

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EUHM Resident Report: Signaling in Stauffer’s Syndrome

The Bottom Line: Against a fundamental contribution for IL-6 in Stauffer’s syndrome is the wide variety of circumstances in which its elevation has no association with inflammatory or cholestatic liver disease. Nevertheless, dysregulated Il-6 acting through disparate signaling cascades is … Continue reading

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EUH Morning Report: In patients with acute alcoholic hepatitis, does steroid therapy increase the risk of GI bleeding compared to no use of steroids?

The Bottom Line: For patients with acute alcoholic hepatitis, there isn’t literature to answer the question of whether steroid therapy increases risk of GI bleeding compared to no use of steroids. For patients with non-acute alcoholic liver disease who do not have concomitant … Continue reading

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VA Resident Report: What is the effectiveness of POEM for achalasia?

Available data suggests POEM is very effective in the relief of symptoms in patients with achalasia. However, POEM is associated with a very high incidence of pathologic reflux. The clinical sequalae of the increase in pathologic reflux are currently incompletely … Continue reading

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VA Resident Report: What are the adverse effects of PPI use on B12 levels?

The Bottom Line: Studies of PPI use and vitamin B12 deficiency have yielded mixed results. Absorption decreased from 3.2 to 0.9% (P ¼ 0.031) in patients on omeprazole 20 mg daily, and from 3.4 to 0.4% in patients on higher … Continue reading

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VA Resident Report: What are the gastrointestinal manifestations of cryptosporidium ?

The cardinal symptom is diarrhea, which is typically watery, and accompanied by abdominal cramps, fatigue, nausea, and anorexia. Fever and vomiting may occur. Diarrhea tends to persist longer (median of 5 to 10 days) than that seen with other etiologies … Continue reading

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VA Resident Report: At what value does hypertriglyceridemia cause acute pancreatitis?

Acute pancreatitis is a relatively common medical condition with variable aetiologies and a mortality up-to 20%. Gallstones and excess alcohol consumption are the leading aetiologies in the developed world; whilst metabolic, congenital and iatrogenic causes are responsible for 20–25% of … Continue reading

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