The Bottom Line: Several clinical variants of pustular psoriasis exist: generalized pustular psoriasis (von Zumbusch type), annular pustular psoriasis, impetigo herpetiformis, and two variants of localized pustular psoriasis—(1) pustulosis palmaris et plantaris and (2) acrodermatitis continua of Hallopeau. Treatment of patients … Continue reading
The Bottom Line: The Nikolsky sign is a moderately sensitive but highly specific tool for the diagnosis of pemphigus. Reference: Uzun, Soner, and Murat Durdu. “The Specificity and Sensitivity of Nikolskiy Sign in the Diagnosis of Pemphigus.” Journal of the … Continue reading
Magnetic resonance imaging (MRI) is the most effective method for documenting the soft tissue lesions and evaluating their distribution. In practice, several key points deserve emphasis: • the absence of MRI abnormalities of the intermuscular fasciae virtually rules out necrotizing … Continue reading
Gameiro, Ana, et al. “Pyoderma gangrenosum: challenges and solutions.” Clinical, Cosmetic and Investigational Dermatology 8(2015):285-93.
Anzalone, Charles L, and Philip RCohen. “Acute febrile neutrophilic dermatosis (Sweet’s syndrome).” Current opinion in hematology 20.1 (2013):26-35.
Bottom line: Typically presents with fever, rash, and solid organ involvement. Commonly associated drugs include aromatic anticonvulsants and sulfonamides. Walsh SA, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. Clin … Continue reading
Bottom line: Some patients infested with scabies do develop eosinophilia. Infestations and bites, scabies. In: Clinical Dermatology, 2009. [MDConsult]. Table 70-1. Diseases, Syndromes, and Conditions Commonly Associated With Peripheral Blood Eosinophilia and/or Tissue Eosinophilia. In: Hematology: Basic Principles and Practice, … Continue reading