Category Archives: Therapy

EUH Morning Report: In patients with acute alcoholic hepatitis, does steroid therapy increase the risk of GI bleeding compared to no use of steroids?

The Bottom Line: For patients with acute alcoholic hepatitis, there isn’t literature to answer the question of whether steroid therapy increases risk of GI bleeding compared to no use of steroids. For patients with non-acute alcoholic liver disease who do not have concomitant … Continue reading

Posted in Applying evidence, EUH, Therapy | Tagged

EUH Krakow Conference: Does empagliflozin cause ketoacidosis?

Bottom Line: An analysis of FDA Adverse Event Reporting System (FAERS) data and three case reports provide evidence that sodium glucose cotransporter 2 (SGLT2) inhibitors (canagliflozin, dapagliflozin, and empagliflozin) cause ketoacidosis. FAERS data A search was done of the FAERS data … Continue reading

Posted in EUH, Therapy

EUH Morning Report: What is the ideal diuretic dosing strategy for diuretics in a patient admitted from home with acute decompensated HF and already on home diuretics?

The Bottom Line: In managing patients admitted with heart failure exacerbation, the DOSE trial confirmed that furosemide (Lasix) intermittent bolus is equivalent to continuous drip, making continuous drip management unnecessary in nearly all situations. Furthermore, symptoms were similar in high dose … Continue reading

Posted in Applying evidence, EUH, Therapy

EUH Resident Report: What are the current guidelines for treating non-CAP pneumonia?

The Bottom Line: Treatment guidelines for hospital-acquired aspiration pneumonia no definitive evidence to inform optimal antibiotic regimen antibiotic choice typically based on setting and concern for anaerobic infection treatment should be based on suspected pathogens pathogenic role of anaerobes and … Continue reading

Posted in EUH, Therapy

EUH Hunt Conference: A review of RCT findings on thrombolytics for pulmonary embolsim

The Bottom Line: Thrombolysis may be considered in selected intermediate-risk PE patients who have evidence of RV dysfunction or myocardial damage or in PE who may be clinically worsening or not improving with anticoagulation, and/or based on patient values or … Continue reading

Posted in Background question, EUH, Therapy

EUH Dressler Conference: What is the most appropriate timeframe for administering IV fluids to patients with sepsis or septic shock?

The Bottom Line: The Surviving Sepsis Guideline states 30cc/kg within first 3 hours for sepsis or shock, as defined by new Sepsis definitions (Singer et al, 2016). References: Leisman D, Wie B, Doerfler M, Bianculli A, et al. Association of … Continue reading

Posted in EUH, Intern toolbox, Therapy

EUH Resident Report: What are the guidelines for prophylaxis for dental procedures in patients with congenital heart disease?

The Bottom Line: Infective endocarditis (IE) prophylaxis for dental procedures should be recommended only for patients with underlying cardiac conditions associated with the highest risk of adverse outcome from IE. For patients with these underlying cardiac conditions, prophylaxis is recommended … Continue reading

Posted in Applying evidence, EUH, Therapy