Category Archives: Therapy

EUH Dressler Conference: What are standard treatments and NSAIDS for pericarditis?

The Bottom Line:  Aspirin or non-steroidal anti-inflammatory drugs are standard first-line therapy for acute pericarditis. Acute pericarditis (for complete information, see DynaMed Plus): ibuprofen 600 mg every 8 hours for 1-2 weeks, then taper by 200-440 mg every 1-2 weeks until … Continue reading

Posted in Applying evidence, EUH, Therapy

EUH Morning Report: Delayed paracentesis and mortality risk with spontaneous bacterial peritonitis

The Bottom Line: In a study of hospitalized patients with spontaneous bacterial peritonitis (SBP), Kim et al (2014) concluded: Patients who receive delayed paracentesis (DP) had a higher in-hospital mortality (27% vs 13%) compared with those who received early paracentesis (EP). … Continue reading

Posted in Diagnosis, EUH, Therapy

EUH Hunt Conference: What trials have been done on early vs. later initiation of ARTs in the hospital for opportunistic infections in the setting of HIV?

The Bottom Line:  Karim et al (2010): An open-label randomized controlled trial in Durban, South Africa to determine optimal timing of ART initiation in relation to TB treatment. Acid-fast bacilli (AFB) smear positive tuberculosis patients with HIV infection and CD4+ counts … Continue reading

Posted in Background question, EUH, Therapy

EUH Morning Report: In patients with acute alcoholic hepatitis, does steroid therapy increase the risk of GI bleeding compared to no use of steroids?

The Bottom Line: For patients with acute alcoholic hepatitis, there isn’t literature to answer the question of whether steroid therapy increases risk of GI bleeding compared to no use of steroids. For patients with non-acute alcoholic liver disease who do not have concomitant … Continue reading

Posted in Applying evidence, EUH, Therapy | Tagged

EUH Krakow Conference: Does empagliflozin cause ketoacidosis?

Bottom Line: An analysis of FDA Adverse Event Reporting System (FAERS) data and three case reports provide evidence that sodium glucose cotransporter 2 (SGLT2) inhibitors (canagliflozin, dapagliflozin, and empagliflozin) cause ketoacidosis. FAERS data A search was done of the FAERS data … Continue reading

Posted in EUH, Therapy

EUH Morning Report: What is the ideal diuretic dosing strategy for diuretics in a patient admitted from home with acute decompensated HF and already on home diuretics?

The Bottom Line: In managing patients admitted with heart failure exacerbation, the DOSE trial confirmed that furosemide (Lasix) intermittent bolus is equivalent to continuous drip, making continuous drip management unnecessary in nearly all situations. Furthermore, symptoms were similar in high dose … Continue reading

Posted in Applying evidence, EUH, Therapy

EUH Resident Report: What are the current guidelines for treating non-CAP pneumonia?

The Bottom Line: Treatment guidelines for hospital-acquired aspiration pneumonia no definitive evidence to inform optimal antibiotic regimen antibiotic choice typically based on setting and concern for anaerobic infection treatment should be based on suspected pathogens pathogenic role of anaerobes and … Continue reading

Posted in EUH, Therapy