Category Archives: Therapy

EUH Resident Report: What are the guidelines for prophylaxis for dental procedures in patients with congenital heart disease?

The Bottom Line: Infective endocarditis (IE) prophylaxis for dental procedures should be recommended only for patients with underlying cardiac conditions associated with the highest risk of adverse outcome from IE. For patients with these underlying cardiac conditions, prophylaxis is recommended … Continue reading

Posted in Applying evidence, EUH, Therapy

EUH Krakow Conference: What are the indications for leukopheresis?

The Bottom Line: The primary indication for leukopheresis is leukostatis, which is seen most frequently in CML and acute leukemia patients, especially AML. Leukopheresis is also occasionally performed in ALL and CLL. Reference: Ganzel C, Becker J, Mintz PD, et al. … Continue reading

Posted in EUH, Therapy

EUH Hunt Conference: What are the treatments and outcomes for anti-GABA(B) associated encephalitis with small-cell lung cancer?

The Bottom Line: GABA(B) encephalitis shows typical clinical patterns of afebrile limbic encephalitis and intractable seizures, and is associated with small-cell lung cancer. Immunomodulation and cancer chemotherapy often improve the neurological deficits (Kim et al 2014). Patients with small-cell lung … Continue reading

Posted in EUH, Prognosis, Therapy

EUH Dressler Conference: What is the serologic course of Hepatitis B?

The Bottom Line: Hepatitis B serologic testing involves measurement of several hepatitis B virus (HBV)-specific antigens and antibodies. Different serologic “markers” or combinations of markers are used to identify different phases of HBV infection and to determine whether a patient … Continue reading

Posted in Background question, EUH, Therapy

EUH Hunt Conference: What are the mechanisms and risks of drug-induced QT prolongation?

The Bottom Line: Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced inhibition of K+ currents, IKs, IKr, IK1, and/or Ito, delay repolarization, … Continue reading

Posted in EUH, Therapy

EUH Resident Report: Fluid management in acute pancreatitis – LR vs. saline

The Bottom Line: Data from the HYSLAR RCT found that fluid restriction with HYS is associated with a trend toward a reduced overall rate of complication when adjusted for pancreatic gland texture alone (21% reduction) and a significant reduction in … Continue reading

Posted in EUH, Therapy

EUH Resident Report: A review of acute pancreatitis.

The Bottom Line: The incidence of acute pancreatitis is increasing in the United States, and the disorder is now one of the most common reasons for hospitalization with a gastrointestinal condition. Accurate diagnosis of acute pancreatitis requires at least two … Continue reading

Posted in Background question, Diagnosis, EUH, Therapy