Author Archives: Hannah

EUH Krakow Conference: What are the causes of nephrotic syndrome?

The Bottom Line: Many underlying systemic conditions can cause nephrotic syndrome (NS), although type 2 diabetes mellitus and systemic lupus erythematosus are most common. NS may not present as a primary diagnosis, but instead as one of multiple disease manifestations, … Continue reading

Posted in Diagnosis, EUH

EUH Krakow Conference: What is the sensitivity of the 4th generation test for acute HIV infection?

The Bottom Line:  A study involving 86,836 participants found the Abbott Architect HIV Ag/Ab Combo Assay to have a 79.8% sensitivity and 99.9% specificity with a positive predictive value of 59% (Peters et al, 2016). Reference: Peters PJ, Westheimer E, … Continue reading

Posted in Diagnosis, EUH, Miscellaneous

EUH Krakow Conference: What causes glomerulonephritis?

The Bottom Line: Membranoproliferative glomerulonephritis (MPGN) is diagnosed on the basis of a glomerular-injury pattern that is common to a heterogeneous group of diseases. Two major pathophysiological factors — the deposition of immunoglobulin and the deposition of complement in the … Continue reading

Posted in Diagnosis, EUH

EUH Hunt Conference: What is plastic bronchitis?

The Bottom Line: Plastic bronchitis (PB) is an uncommon pulmonary disease characterized by production of cohesive and branching casts filling the airways. The diagnosis of PB is confirmed by a history of expectoration of branching airways casts, or by removing … Continue reading

Posted in Background question, Diagnosis, EUH, Teaching pearls

EUH Dressler Conference: What is the risk of PE for patients with syncope?

The Bottom Line: Up to 1 in 6 admitted syncope patients may have PE – Works out to <4% of ED presenters with loss of consciousness (LOC), and likely <<1% of all syncope cases (which includes patients who do not … Continue reading

Posted in Diagnosis, EUH

EUH Dressler Conference: What is the pathophysiology of disseminated intravascular coagulation (DIC)?

The Bottom Line: DIC is a systemic pathophysiologic process and not a single disease entity. The massive tissue factor stimulus results in excess intravascular thrombin, which overcomes the anticoagulant systems and leads to thrombosis. Because of consumption of coagulation factors … Continue reading

Posted in Background question, EUH

EUH Dressler Conference: Can blood pressure index (BPI) be a predictor of right ventricular dysfunction in PE?

The Bottom Line: A recent study found the ratio of systolic to diastolic blood pressure ≤1.7 to be a strong indicator of right ventricle dysfunction. In his review of the article, Pallin (2017) notes that the results should not change … Continue reading

Posted in Diagnosis, EUH