Author Archives: Kevin

Grady Morning Report: What are the current guidelines concerning the management of acute pulmonary embolism (PE)?

The Bottom Line: Only one of the phase 3 clinical trials investigating the use of new direct oral anticoagulants in patients with VTE reported efficacy results for the subgroup of patients with acute PE and RV dysfunction. Among patients with … Continue reading

Posted in Background question, Grady, Therapy | Tagged

Kokko Conference: Is Vitamin B12 deficiency one of the etiological causes of pancytopenia?

The Bottom Line: The etiological causes of pancytopenia vary depends on patients’ age, gender, country, and other conditions. Vitamin B12 deficiency is the most common treatable cause of pancytopenia. Reference: Yokuş O, Gedik H. Etiological causes of pancytopenia: A report … Continue reading

Posted in Applying evidence, Grady

Kokko Conference: Does TTP (thrombotic thrombocytopenic purpura) result in ARDS (acute respiratory distress syndrome)?

The Bottom Line: Life-threatening ARDS can be associated with TTP. Early recognition of ARDS associated with TTP and timely EP is critical to a favorable outcome. Summary: Experience suggests that ARDS may occur as a clinical feature of either de novo … Continue reading

Posted in Grady, Prognosis

Kokko Conference: Do protease inhibitors lead to improved outcomes in AL cardiac amyloidosis?

The Bottom Line: . In a study of diflunisal in ATTR cardiac amyloidosis (both mutant and wt), stable mean left ventricular (LV) mass, LVEF and cardiac biomarkers were seen during the course of therapy.  Nephrotoxicity and volume overload was observed as … Continue reading

Posted in Grady, Therapy

Grady Report: What are the current guidelines for the pharmacological management of prostatitis?

The Bottom Line: For healthcare providers, the focus of therapy is symptomatic relief. The first therapeutic measure is often a 4- to 6-week course of a fluoroquinolone, which provides relief in 50% of men and is more efficacious if prescribed … Continue reading

Posted in Background question, Grady, Therapy

What are the guidelines for management of seizures in alcohol-dependent individuals?

The Bottom Line: Alcohol withdrawal seizures should be promptly treated with benzodiazepines, clomethiazole or barbiturates to prevent status epilepticus. Reference: Hillbom M, Pieninkeroinen I, Leone M.  Seizures in Alcohol-Dependent Patients: Epidemiology, Pathophysiology and Management.  CNS Drugs. 2003;17(14):1013-30. Summary: In conclusion, there is powerful … Continue reading

Posted in Background question

What are the neurologic sequelae of NSAID toxicity, and do these include aseptic meningitis?

The Bottom Line: One of the important neurologic side-effects attributed to the over-use of NSAIDs is aseptic meningitis. Reference: Auriel et al.  Nonsteroidal anti-inflammatory drugs exposure and the central nervous system.  Handb Clin Neurol 2014;119:577-84. Summary: CNS effects of NSAID toxicity range … Continue reading

Posted in Background question, EUH | Tagged