EUH Hunt Conference: What is the history of hand, foot, mouth disease in adults?

The Bottom Line: Most commonly diagnosed in children, hand, foot, mouth disease (HFMD) infects approximately 11% of exposed adults, and less than 1% of those infected experience clinical manifestations of the disease (Ramirez-Fort et al, 2014). Most cases resolve on their own, yet supportive treatment can alleviate fever, pain and inflammation (DyanMed Plus, 2018).

References:  DynaMed Plus [Internet]. Ipswich (MA): EBSCO Information Services. 1995 – . Record No. 116931, Hand-foot-and-mouth disease; [updated 2018 Feb 22, cited 2018 Jun 19]; [about 10 screens]. Available from http://www.dynamed.com/login.aspx?direct=true&site=DynaMed&id=116931. Emory login required.

Ramirez-Fort MK, Downing C, Hung Q, et al. Coxsackievirus A6 associated hand, foot and mouth disease in adults: Clinical presentation and review of the literature. J Clin Virol. 2014 Aug;60(4):381-6. Doi:10.1016/j.jcv.2014.04.023

Summary: Complications are rare but can include the following (DynaMed Plus, 2018):

  • temporary nail shedding
  • myocarditis
  • pulmonary edema
  • neurologic complications
    • viral oraseptic meningitis
    • brainstem encephalitis
    • neurogenic pulmonary edema
    • acute flaccid paralysis
    • opsoclonus-myoclonus syndrome
    • cerebellar ataxia
    • Guillain-Barre syndrome
    • transverse myelitis
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