The Bottom Line: The duration of protection in children and adults resulting from hepatitis B vaccination is unknown. In a 30-year study done on 1528 Alaska Natives it was found, based on anti-HBs level ≥10 mIU/mL at 30 years and an 88% booster dose response, that ≥90% of participants had evidence of protection 30 years later. Booster doses are not needed.
Reference: Bruce MG, Bruden D, Hurlburt D, Zanic C, et al. Antibody levels and protection after hepatitis b vaccine: Results of a 30-year follow-up study and response to a booster dose. Journal of Infectious Diseases. 2016 July; 214(1): 16-22. Doi: 10.1093/infdis/jiv748.
Summary: Among 243 persons (56%) who responded to the original primary series but received no subsequent doses during the 30-year period, 125 (51%) had an anti-HBs level ≥10 mIU/mL. Among participants with anti-HBs levels