EUHM Resident Report: Does pregnancy increase or decrease the risk of lupus flares?

The Bottom Line: SLE patients with stable lupus nephritis demonstrates that flares develop in almost 20% of pregnancies, but flares respond to prompt and adequate therapy. On the same level, contraception and an optimal timing for pregnancy should be discussed with patients, particularly when anti-phospholipid and anti-Ro/SSA antibodies are present.

References: Doria, A., Gershwin, M., & Selmi, C. (2016). From old concerns to new advances and personalized medicine in lupus: The end of the tunnel is approaching. Journal of Autoimmunity, 74, 1-5.

Summary: The best news in SLE is related to pregnancy management as the disease most frequently affects women of childbearing age. If in the past pregnancy was “contraindicated” because of the high risk of flares, pregnancies can now be successful after the diagnosis SLE, even if with some precautions .

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