In susceptible individuals, inhalation of Aspergillus spores can affect the respiratory tract in many ways. These spores get trapped in the viscid sputumof asthmatic subjects which triggers a cascade of inflammatory reactions that can result in Aspergillus-induced asthma, allergic bronchopulmonary aspergillosis, and allergic Aspergillus sinusitis. An immunologically mediated disease, ABPA, occurs predominantly in patients with asthma and cystic fibrosis.
Shah, A., & Panjabi, C. (n.d.). Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity. Allergy, Asthma & Immunology Research., 8(4), 282-297.
Once the disease was recognized in the United States in 1968 and thence globally, the key diagnostic features have been standardized. Based on clinical, radiologic, and laboratory features, a set of 8 major and 3 minor criteria was proposed in 1977 by Rosenberg and Patterson, which remains the most well-acknowledged criteria.
Table 2. Evolving diagnostic criteria for ABPA Page 285