EUH Resident Report: Pathophysiology of Takayasu arteritis in ACA.

The Bottom Line:  In four of the seven cases, an inflammatory process was the cause of the ACA, and the histopathological findings were compatible with typical chronic lesions of Takayasu’s arteritis in the aortic wall. It is well known that Takayasu’s arteritis reflects systemic vasculitis and most commonly affects the aorta and its branches.

Reference: Janzen J., Vuong PN, and Rothenberger-Janzen K. Takayasu’s arteritis and fibromuscular dysplasia as causes of acquired atypical coarctation of the aorta: A retrospective analysis of seven cases. Heart Vessels 1999; 14(6): 277-282.

Summary: The analysis of these seven cases demonstrated that a histopathological examination of the coarctations is necessary in order to prove the etiology. The surgical procedures performed were dictated by technical considerations of the location/extent of the coarctate process without regard to its etiology. Similar lesions caused by end-stage Takayasu’s arteritis or FMD were remedied by the same surgical procedure. From a histological point of view, pathological processes with different localizations in the aortic wall exist as causes of the ACA. These are: (1) fibrosis/scarification in the tunica media and adventitia compatible with chronic or end-stage lesions of Takayasu’s arteritis, and (2) FMD in the tunica media.

This entry was posted in Background question, EUH. Bookmark the permalink.