In this study, all patients with cholecystitis (except two) had the final diagnosis confirmed at cholecystectomy. Of the patients with cholecystitis, four were acute and 14 were chronic. Among those in the group with hepatocellular disease 8 had alcoholic liver disease.
Rosenthall, L., Shaffer, E., Lisbona, R., & Pare, P. (n.d.). Diagnosis of hepatobiliary disease by 99mTc-HIDA cholescintigraphy. Radiology., 126(2), 467-474.
In cholestasis, often with just a modest hyperbilirubinemia, the impaired excretion of contrast material does not allow adequate visualization of the biliary tree and gallbladder. Several radiolabeled substances which were recently introduced for the clinical investigation of hepatobiliary disease appear to have overcome some of these problems. In animal and human studies they were shown to be nontoxic materials, rapidly cleared by the liver, and excreted into the bile duct in sufficient concentrations to render good identification of the gall bladder and bile ducts
Fig. 6. Cholestatic alcoholic hepatitis: a comparison between 131 I-rose bengal and 99mTc-HIDA. The Iiver-to background ratio is considerably higher with the former.