The Bottom Line: In this study, the BNP level of the high-risk group (PSI classes IV and V) was significantly higher (P<0.01) than that of the low-risk group (PSI classes I-III). There was a significant positive correlation (r=0.782, P<0.001) between the level of BNP and PSI. Though the PSI has been accepted as a standard evaluation of pneumonia severity, the BNP level may indicate the severity of CAP. The results of the present study also showed that BNP is significantly superior to CRP and WBC in severity prediction. Therefore, the BNP level may be important for predicating the severity of CAP in clinical practice.
Li, Jing, HuanYe, and Li iZhao. “B-type natriuretic peptide in predicting the severity of community-acquired pneumonia.” World Journal of Emergency Medicine 6.2 (2015):131-6. http://sfxhosted.exlibrisgroup.com/emu?sid=Entrez%3APubMed&id=pmid%3A26056544&issn=1920-8642
Community-acquired pneumonia is a leading infectious cause of death in developed countries. The timely and accurate evaluation of CAP severity is helpful to reduce the mortality, shorten hospital stay and save medical resources. It has been reported that pneumonia severity index is closely associated with the mortality of patients, and has been widely used to evaluate the severity of CAP. However, the calculation of PSI is complicated and liable to personal errors. Researchers have found that the risk stratification of various infective patients can be simplified by use of biomarkers.