Responsive Nerve Simulator (RNS) for Epilepsy

How it works

“The RNS® System (NeuroPace, Mountain View, CA) provides responsive cortical stimulation via a cranially implanted programmable neurostimulator connected to 1 or 2 recording and stimulating depth or subdural cortical strip leads that are surgically placed in the brain according to the seizure focus. The neurostimulator continually senses electrocorticographic activity and is programmed by the physician to detect abnormal electrocorticographic activity and then provide stimulation. The physician adjusts detection and stimulation parameters for each patient to optimize control of seizures.” The source article by Morrell includes information on its effectiveness.

Brief notes on the neurostimulator, cortical strip leads, depth leads, remote monitor, want, magnet, programmer, want, and patient data management system (PDMS) for the NeuroPace RNS can be found here.

Additional information

NeuroPace RNS user manuals for patients and physicians are available here.

The NeuroPace RNS is intended for patients who have been diagnosed as having no more than 2 seizure foci, have not responded to two or more anti-epileptic medications, and are currently having frequent, disabling seizures. Here is the source.

Citation for source article by Morrell

Morrell, Martha J. “Responsive cortical stimulation for the treatment of medically intractable partial epilepsy.” Neurology 77.13 (2011):1295-304.


About Lisa

I have been a Clinical Informationist (aka Medical Librarian) for Emory University since September 2013. Prior to that, I was a Medical Librarian for Lincoln Memorial University (LMU) from March 2007 to August 2013 and served its DeBusk College of Osteopathic Medicine, Caylor School of Nursing, and allied health programs. From January 2002 - March 2007, I served the Medical Assisting (MA), Occupational Therapy Assistant, Physical Therapy Assistant, Radiologic Technologist, and Nursing programs at South College in Knoxville, Tennessee. I graduated from The University of Tennessee School of Information Sciences with a Master of Science degree in December 2000.
This entry was posted in Background question, EUH, Therapy and tagged . Bookmark the permalink.