McDonald criteria for diagnosis of multiple sclerosis

Bottom line: Table 3 from study by the Magnims European research network provides estimated data (95% confidence interval) for sensivity, specificity, accuracy, positive predictive value, positive likelihood ratio, and negative likelihood ratio for old and new McDonald criteria (divided up by overall criteria (dissemination in space (DIS) and dissemination in time (DIT)), DIS criteria, DIT criteria, and DIT on follow-up scan. Table 3 is available here.

McDonald criteria:
The revised criteria includes key changes related to use and interpretation of DIS and DIT imaging criteria as stated in published study by the Magnims European research network. The authors of the revised McDonald criteria (2011) claim that the criteria have been simplified while preserving diagnostic sensitivity and specificity, addressing their applicability across various populations, and possibly allowing them to be used widespread and more uniformly.


Revised McDonald criteria:
Polman, Chris H, et al. “Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.” Annals of neurology 69.2 (2011):292-302.

Study by Magnims European research network:
Swanton, Josephine K, et al. “MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study.” Lancet neurology 6.8 (2007):677-86.



About Lisa

I have been a Clinical Informationist (aka Medical Librarian) for Emory University since September 2013. Prior to that, I was a Medical Librarian for Lincoln Memorial University (LMU) from March 2007 to August 2013 and served its DeBusk College of Osteopathic Medicine, Caylor School of Nursing, and allied health programs. From January 2002 - March 2007, I served the Medical Assisting (MA), Occupational Therapy Assistant, Physical Therapy Assistant, Radiologic Technologist, and Nursing programs at South College in Knoxville, Tennessee. I graduated from The University of Tennessee School of Information Sciences with a Master of Science degree in December 2000.
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