What is the relationship between Neutrophil gelatinase-associated lipocalin and hepatorenal syndrome?

The Bottom Line: This study included 64 patients with cirrhosis and 23 control subjects. Patients with type 1 and type 2 HRS had significantly higher plasma and urine NGAL levels compared with stable cirrhosis and control subjects. This study concluded NGAL could predict mortality in patients with HRS independent of other commonly used risk factors.

Gungor, Gokhan, et al. “Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study.” Liver international 34.1 (2014):49-57.

Hepatorenal syndrome is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase-associated lipocalin is a troponin-like biomarker for human acute kidney injury. This study was designed to investigate levels of plasma and urine NGAL in HRS and the predictive ability of these markers for all-cause mortality, in HRS, stable cirrhosis and control subjects.

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