What is the sensitivity and specificity of Yamaguchi Criteria for the diagnosis of Adult Onset Stills Disease?

Lian, Fan, et al. “Clinical features and hyperferritinemia diagnostic cutoff points for AOSD based on ROC curve: a Chinese experience.” Rheumatology international 32.1 (2012):189-92.

Statistical ability of combined Yamaguchi criteria and ferritin for AOSD diagnosis

Yamaguchi criteria for AOSD had a sensitivity of 96.2% and a specificity of 92.1%.

Table 3 shows the sensitivity and specificity of combined Yamaguchi criteria and hyperferritinemia.

Table 3  Combined Yamaguchi criteria and hyperferritinemia

Sensitivity (%)                   Specificity (%)

Ferritin ≥750 µg/L                   83.5                                98.8

Ferritin ≥1,250 µg/L                 70.9                               99.3

Ferritin ≥2,500 µg/L                 43.0                                99.9

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