efficacy of Tamiflu (oseltamivir phosphate)

Bottom line: The Cochrane Collaboration concluded that benefits and harms need to be considered when deciding to use Tamiflu for prevention and treatment of influenza in healthy adults and children. A systematic review of systematic reviews concluded that “the combination of diagnostic uncertainty, the risk for virus strain resistance, possible side effects and financial cost outweigh the small benefits of oseltamivir…for the prophylaxis and treatment of healthy individuals.” Flanner and Bastin stated that additional data is needed to reach a definitive conclusion, but in critically ill patients the current literature “does not support routine use of high-dose oseltamivir in critically ill patients.”  Summary of evidence:

Jefferson, Tom, et al. “Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children.” Cochrane Database of Systematic Reviews 4(2014):CD008965. The full report covers the controversy with regard to the efficacy of Tamiflu.

Michiels, Barbara, et al. “The value of neuraminidase inhibitors for the prevention and treatment of seasonal influenza: a systematic review of systematic reviews.” PLoS ONE 8.4 (2013):e60348.

Flannery, Alexander H, and Melissa L Thompson Bastin. “Oseltamivir dosing in critically ill patients with severe influenza.” The Annals of pharmacotherapy 48.8 (2014):1011-1018.

 

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About Lisa

I have been a Clinical Informationist (aka Medical Librarian) for Emory University since September 2013. Prior to that, I was a Medical Librarian for Lincoln Memorial University (LMU) from March 2007 to August 2013 and served its DeBusk College of Osteopathic Medicine, Caylor School of Nursing, and allied health programs. From January 2002 - March 2007, I served the Medical Assisting (MA), Occupational Therapy Assistant, Physical Therapy Assistant, Radiologic Technologist, and Nursing programs at South College in Knoxville, Tennessee. I graduated from The University of Tennessee School of Information Sciences with a Master of Science degree in December 2000.
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