Do NSAIDs cause acute pancreatitis?

Bottom line: Limited evidence implicates some NSAIDs as uncommon causes of acute pancreatitis.
Summary: Drug-induced pancreatitis is the third most common cause of acute pancreatitis, comprising approximately 5% of all cases (Dig Dis Sci. 2010 Oct;55(10):2977-81). DynaMed’s entry for sulindac lists pancreatitis as an adverse effect and provides Merck’s prescribing information as the source (See Sulindac > Cautions and Adverse Effects > Warnings/Precautions > Major Toxicities. In: DynaMed). Case reports implicate mesalamine (Am J Gastroenterol. 1997 Dec;92(12):2302-303; Korean J Gastroenterol. 2007 Dec;50(6):379-83). Searches of implicate sulindac, ketorolac, meloxicam, mefenamic acid, naproxen, piroxicam, nabumetone, diclofenac, ibuprofen, and celecoxib (J Clin Gastroenterol. 2005 Sep;39(8):709-16), and lists pancreatitis as a possible side effect in the entries for the first six medications in the aforementioned list.

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About Lisa

I have been a Clinical Informationist (aka Medical Librarian) for Emory University since September 2013. Prior to that, I was a Medical Librarian for Lincoln Memorial University (LMU) from March 2007 to August 2013 and served its DeBusk College of Osteopathic Medicine, Caylor School of Nursing, and allied health programs. From January 2002 - March 2007, I served the Medical Assisting (MA), Occupational Therapy Assistant, Physical Therapy Assistant, Radiologic Technologist, and Nursing programs at South College in Knoxville, Tennessee. I graduated from The University of Tennessee School of Information Sciences with a Master of Science degree in December 2000.