The Bottom Line: This study frequently observed mild, usually brief, liver disorders, with evidence of liver cell damage (15%) or cholestasis (87%). Elevated levels of IgA were found in 118 of the 196 patients tested (60%). Positive anti-neutrophil cytoplasmic antibody was found in 4 of the 105 patients tested (3.8%).
Pillebout, EvangÃline, et al. “Henoch-SchÃÂ¶nlein Purpura in adults: outcome and prognostic factors.” Journal of the American Society of Nephrology 13.5 (2002):1271-1278.
Henoch-Scho¨nlein Purpura nephritis (HSPN) has been extensively studied in children but, its natural history in adults is much less known. Henoch-Schönlein purpura is a leukocytoclastic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is characterized by the association of skin, joint, and gastrointestinal manifestations that may occur in successive episodes. In addition to these manifestations, renal involvement is common, and the long-term prognosis depends on its severity.