Bottom line: There is evidence that administering prophylactic probiotics in patients on antibiotics can reduce the risk of C. diff infection without increasing the risk of adverse events. Probiotics will definitely benefit patients at high-risk for developing Cdiff.
This systematic review assessed RCTs including adult and pediatric patients on antibiotics if the study compared any strain or dose of probiotic with placebo or not treatment and measured incidence of C diff associated diarrhea. RESULTS: Forest plot pooling CDAD incidence in both groups (Fig. 1) favors the probiotic group (RR, 0.34, 95% CI: 0.24-0.49). Relative risk for adverse events (Fig. 2) showed no difference between the groups (RR, 0.82, 95% CI: 0.65-1.05).