Firestein: Kelley’s Textbook of Rheumatology, 9th ed.
Copyright © 2012 Saunders, An Imprint of Elsevier
Clinical Features of Articular BASIC CALCIUM PHOSPHATE Crystal Disease
Patients with advanced chronic renal failure, particularly on dialysis, may develop symptomatic articular and periarticular BCP crystal deposition, which may be destructive and involve the axial skeleton. In some cases of dialysis-dependent renal failure, destructive arthropathy associated with BCP crystal deposition may resemble or be associated with CPPD deposition disease, and monosodium urate crystal deposits in the joint also may occur in the setting. Hyperparathyroidism can promote BCP-associated arthropathy and periarticular disease including calcific bursitis. Clinically significant periarticular HA crystal deposition also may occur in certain post-traumatic conditions and the systemic autoimmune diseases scleroderma and dermatomysositis.