What is the sensitivity of an elevated serum lipase for acute pancreatitis?

Acute pancreatitis

lipase

lasts 72 hours (longer than amylase)
elevated lipase is most accurate enzyme for diagnosis of acute pancreatitis
based on 2 cohort studies
prospective study of 328 patients
lipase > 208 units/L had 67% sensitivity and 97% specificity
serum total amylase > 176 units/L had 45% sensitivity and 97% specificity
urinary total amylase > 550 units/L had 62% sensitivity and 97% specificity
serum pancreatic isoamylase > 41 units/L had 63% sensitivity and 85% specificity
Reference – ANZ J Surg 2001 Oct;71(10):577
lipase > 3 times normal had 100% sensitivity and 99% specificity for acute pancreatitis in study of 170 patients with abdominal pain (Am J Gastroenterol 1993 Dec;88(12):2051)

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