Review of Bartter’s Syndrome

The Bottom Line: Bartter syndrome results from congenital defects in renal tubular handling of sodium, potassium and chloride. The location of the defect is at the thick ascending limb of the loop of Henle.

Fremont, Oliver Understanding Bartter syndrome and Gitelman syndrome. World journal of pediatrics 2012 vol:8 iss:1 pg:25 -30

Bartter syndrome is typically treated with indomethacin and potassium chloride. The dose of indomethacin can be as high as 2-3 mg/kg per day (mean: 2.1 mg/kg per day in one study).

Table. Bartter syndrome and Gitelman syndrome: genetic and clinical fi ndings. All patients show hypokalemic metabolic alkalosis, except type 2 Bartter neonates, who initially show transient hyperkalemic metabolic acidosis Page 27

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