Does altered mental status state a prognostic significance for TTP?

Thrombotic thrombocytopenic purpura (TTP)

• reduced level of consciousness at presentation associated with higher mortality
• based on cohort of 70 patients with TTP treated with plasma exchange
• 6 of 13 (47%) patients with coma/semicoma at presented died
• 4 of 57 (7%) patients without coma/semicoma died
• Reference – Am J Hematol 1997 Feb;54(2):102

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