What is the sensitivity of antimitochondrial antibody in diagnosing primary biliary cirrhosis?

Bottom line: Antimitochondrial antibodies (AMA) have a high sensitivity and specificity for diagnosing primary biliary cirrhosis.

Details: Primary Biliary Cirrhosis (PBC) entry in DynaMed Plus

Reports sensitivity 90%-95% and specificity more than 99%

References Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ, American Association for Study of Liver Diseases. Primary biliary cirrhosis. Hepatology. 2009 Jul;50(1):291-308.

Lindor cites study reporting that AMA is present in 90-95% of patients with PBC and less than 1% of normal controls. Another study reported “fewer than 5% of patients with PBC are AMA-negative.”

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About Amy

Clinical Informationist at EUH Branch Library
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