Is there an association between infection and increased incidence of acute coronary syndrome?

The Bottom Line: It is suggested by increasing bodies of evidence that infections also play a role as risk factor for development of atherosclerosis in arterial walls, with complications such as chronic coronary heart disease,acute myocardial infarction. Infections may act through or along with, the same elements as classic risk factors.

Mattila, K J. Role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke. Clinical infectious diseases 1998 vol:26 iss:3 pg:719 -734

The idea of infection as a risk factor for atherosclerosis and related diseases is not new. Evidence that links infection to cardiovascular diseases has accumulated since the early 1970s and includes different infectious agents that causes different infectious processes: persistent or latent infections. The mechanisms also probably vary, ranging from subtle, cytokine-mediated alterations in blood vessel endothelial function to a marked temporary shift of the blood coagulation mechanism to a thrombogenic direction.

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