The Bottom Line: For uncomplicated catheter related blood stream infections, management generally includes catheter removal and a course of antibiotics of variable duration, depending on species. For uncomplicated coagulase negative staph, catheter salvage may be considered when combined with both systemic antibiotics and an “antibiotic lock” technique. See attached algorithm for more specific details.
Mermel, Leonard. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clinical infectious diseases 2009 vol:49 iss:1 pg:1 -45
Click here to view Algorithm: Figure 2 Approach to the management of patients with short-term central venous catheter-related or arterial catheter-related bloodstream infection. CFU, colony-forming units; S. aureus, Staphylococcus aureus.