Bottom line: According to ADQI classification, renal failure is defined as
- changes in serum creatinine: increase in serum creatine 3 times baseline and GFR decrease by 75% OR a serum creatinine ≥4 mg/dl
- changes in urine output: Urine output < 0.3 ml/kg/h x 24 hours OR anuria x 12 hours
- changes in both
Bellomo R, et al. Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Critical Care 2004, 8:R204-R212.
Fig 1. (p. R204) Proposed classification scheme for acute renal failure. Classification of borderline, injury and failure through ESKD based on changes in creatinine, urine output or both.