Review of Fibrillary Glomerulonephritis

The Bottom Line: Fibrillary Glomerulonephritis occurs in approximately 1% of native kidney biopsies.

Alpers, Charles Glomerulonephritis and Immunotactoid Glomerulopathy: J Am Soc Nephrolo 19: 34-37, 2008

 The distinctive features are infiltration of glomerular structures by randomly arranged fibrils similar in appearance but larger than amyloid fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. It is widely but not universally recognized to be distinct from immunotactoid glomerulopathy, an entity characterized by glomerular deposits of immunoglobulin with substructural organization as microtubules and with clinical associations with lymphoplasmacytic disorders.

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