What is the difference between cerebral salt wasting and SIADH?

Bottom line:  Cerebral salt wasting is associated with hypovolemic hyponatremia in patients with intracranial disease, such as subarachnoid hemorrhage, traumatic brain injury, craniotomy, encephalitis, and meningitis.  SIADH is a cause of euvolemic hyponatremia due to the excess secretion of vasopressin that may be attributed to malignancy, various CNS or pulmonary disorders or drugs, such as chlorpropamide and carbamazepine.

 For more information:

Table 19–12 Causes of SIADH.  In:  Pathophysiology of Disease [AccessMedicine]

 Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis.  N Engl J Med. 2007 May 17;356(20):2064-72.

About Amy

Clinical Informationist at EUH Branch Library
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