Review of post-thrombotic syndrome

The Bottom Line: PTS develops in up to 50% of patients after symptomatic deep venous thrombosis and is the most common complication. Usual components include chronic pain, swelling, heaviness, oedema and skin changes in the affected limb. Symptoms may appear in varying combinations and be intermittent or persistent.

Kahn The post-thrombotic syndrome: progress and pitfalls. British journal of haematology 2006 vol:134 iss:4 pg:357 -365

Summary: PTS is defined as a syndrome and there is no gold standard lab, imaging or functional test that will establish diagnosis. Patients with objectively confirmed prior deep venous thrombosis who has symptoms and signs, the correct diagnosis is usually PTS. In some it may take approximately 3–6 months for the initial pain and swelling associated to resolve, so a diagnosis of PTS should be deferred until after the acute phase..

Table I. Typical clinical features of the post-thrombotic syndrome. Page 358

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