Bottom Line: Specificity of AMA is more than 99% and sensitivity is 90-95%.
DynaMed cites reports included in American Association for the Study of Liver Disease (AASLD) recommendations that include diagnosis based on meeting 2 of these 3 criteria:
-Biochemical evidence of cholestasis based mainly on alkaline phosphatase elevation.
-Presence of AMA.
-Histologic evidence of nonsuppurative destructive cholangitis and destruction of interlobular bile ducts
For review of evidence of AMA specificity (under Etiology, p. 291) and a suggested diagnostic algorithm (Fig 1., p. 292), see
Lindor KD, et al. Primary biliary cirrhosis. Hepatology. 2009; 50(1):291-308.