What is the sensitivity of anti-histone for drug-induced SLE?

Bottom line:  Anti-histone test is very sensitive, but non-specific for drug-induced SLE.

Summary: Lane SK, et al.  Clinical Utility of Common Serum Rheumatologic Tests. Am Fam Physician. 2002 Mar 15;65(6):1073-1081.
Reviews utility of various rheumatologic tests. Table 2 summarizes sensitivity of positive antinuclear antibody test for various conditions.
Drug-induced Lupus Erythematosus, Antihistone, and Antichromatin Antibodies. In: Henry’s Clinical Diagnosis and Management by Laboratory Methods, 2006.
Discusses ANA in setting of suspected drug-induced SLE.


About Amy

Clinical Informationist at EUH Branch Library
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