Bottom line: Anti-histone test is very sensitive, but non-specific for drug-induced SLE.
Summary: Lane SK, et al. Clinical Utility of Common Serum Rheumatologic Tests. Am Fam Physician. 2002 Mar 15;65(6):1073-1081.
Reviews utility of various rheumatologic tests. Table 2 summarizes sensitivity of positive antinuclear antibody test for various conditions.
Drug-induced Lupus Erythematosus, Antihistone, and Antichromatin Antibodies. In: Henry’s Clinical Diagnosis and Management by Laboratory Methods, 2006.
Discusses ANA in setting of suspected drug-induced SLE.