The Bottom Line: Adult Kawasaki Disease is rare and may go unrecognized. It has similar clinical presentations as hypersensitivity drug reaction and toxic shock syndrome which must be ruled out.
Pascal Sève MD. Adult Kawasaki disease: report of two cases and literature review. Seminars in arthritis and rheumatism 2005 vol:34 iss:6 pg:785 -92
The etiology of Kawasaki Disease is unknown. Numerous immunologic abnormalities have been described during the acute phase including lymphopenia, increased CD4+ activated T-cell count, and increased cytokine levels. Also, infectious agents, such as Propionibacterium acnes, Rickettsia, Epstein-Barr virus, parvovirus B19, and retroviruses, are thought to be possible etiological agents. A role of one or more superantigens, produced by certain strains of Staphylococcus or Streptococcus or HIV, and capable of stimulating large numbers of T-cells, is also a suspect. In adultswith suspected KD, toxic shock syndrome is the most important disease to rule out.