Is prophylaxis for PCP effective in an immunocompromised non-HIV patient?

Bottom line:  Prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) appears to be effective in immunocompromised patients without HIV infection.

SummaryCochrane Database Syst Rev 2011 Jan 19;(1):CD005590

Systematic review of 11 RCTs or quasi-RCTs including (1155 patients) between 1974 and 1997  comparing TMP-SMX to placebo or to fluoroquinolones.  Only a few of the trials included descriptions of randomization and allocation concealment procedures.

RESULTS:  Forest plot in Analysis 1.1 shows that compared to placebo or to other treatment, TMP-SMX provides statistically significant benefit (

How I found it:  DynaMed (PCP article)


About Amy

Clinical Informationist at EUH Branch Library
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