Dermatomyositis, Polymyositis, and Inclusion Body Myositis. In: Hospital for Special Surgery Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy (Ovid)
Antisynthetase syndrome occurs in a subset of patients with polymyositis and who possess antibodies to the enzymes that bind tRNA to amino acids for transporting the amino acids to the ribosome for protein synthesis. Anti-Jo1, the antihistidyl-tRNA synthetase, is the most common. Patients with the antisynthetase syndrome have interstitial lung disease, Raynaud’s phenomenon, small joint arthritis, thickening of the skin known as mechanic’s hands, and inflammatory myopathy.
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