How does heparin induce hyperkalemia and what other drugs can be associated with hyperkalemia?

According to the section for medication-related hyperkalemia in Brenner & Rector’s The Kidney, 10th edition, the following drugs can induce hyperkalemia by impairing renin-aldosterone elaboration/fuction:

  • Cyclooxygenase inhibitors (NSAIDs)
  • Cyclosporine and tacrolimus
  • Epithelial sodium channel inhibitors (amiloride, trimethoprim, and pentamidine)
  • Angiotensin-converting enzyme inhibitors
  • Mineralocorticoid and angiotensin antagonists (ARBs (angiotensin receptor blockers))

Ben Salem et al.  Drug-induced hyperkalemia. Drug Saf. 2014 Sep;37(9):677-92.
This review article addresses drugs included in Brenner & Rector’s book and provides an overiew of the mechanisms involved.

Updated 2/13/2016

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About Amy

Clinical Informationist at EUH Branch Library
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