What are the staging and prognostic criteria for Hodgkin’s disease?

Figure 1Modified Ann Arbor staging system for hodgkin lymphoma

Table 105-1. In: Abeloff’s Clinical Oncology, 5th ed. Accessed 2/19/16.

International Prognostic Factors

Hasenclever D, Diehl V. A prognostic score for advanced Hodgkin’s disease. International Prognostic Factors Project on Advanced Hodgkin’s Disease. N Engl J Med. 1998 Nov 19;339(21):1506-14.
This article describes the International Prognostic Factors score, which was utilized in a recently presented case to determine prognosis and treatment options.  The score is defined as the sum of the following adverse prognostic indicators present at diagnosis:

serum albumin level < 4 g/deciliter
hemoglobin level < 10.5 g/deciliter
male sex
age of 45 years or older
stage IV disease (according to the Ann Arbor classification)
white-cell count of at least 15,000 per cubic millimeter
lymphocytopenia (a lymphocyte count < 600 per mm3, a count < 8 % of the white-cell count, or both)

Figure 1 compares the overall survival for predicted rates using the prognostic score to that for 1600 patients with advanced disease


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