Wormser GP, et al. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006 Nov 1;43(9):1089-134.
For suspected lyme disease, (see p.1090) single dose of doxycycline in the setting of all of these:
• the attached tick can be reliably identified as an adult or nymphal I. scapularis tick that is estimated to have been attached for at least 36 h on the basis of the degree of engorgement of the tick with blood or of certainty about the time of exposure to the tick
• prophylaxis can be started within 72 h of the time that the tick was removed
• ecologic information indicates that the local rate of infection of these ticks with B. burgdorferi is_20%
• doxycycline treatment is not contraindicated.
For suspected Ehrlichiosis, (see p. 1094) start treatment with doxycycline immediately with a suggestive clinical presentation while waiting for lab tests
For suspected tularemia, start antibiotic treatment immediately with a suggestive clinical presentation while waiting for lab tests
Tularemia. Dynamed. 2009. See Treatment section for summary of evidence on various regimens