For patients with cancer, is the site of the cancer associated with varying risk for VTE?

Khorana AA, et al. Frequency, risk factors, and trends for venous thromboembolism among hospitalized
cancer patients. Cancer. 2007 Nov 15;110(10):2339-46.

Objective: To document rates and risk factors of VTE in hospitalized cancer patients who had a diagnosis of venous thrombosis or pulmonary embolism.

Short answer:  Overall rate of VTE for this cohort was 4.1%.  Cancer sites associated with increased rate of VTE were pancreas, abdominal (other than stomach, colon, rectum), kidney, ovary, lung, brain

Methods: Retrospective study using discharge data of 1,015,598 cancer patients hospitalized between 1995 and 2003 at multiple US medical centers.  Identified VTE and site of cancer by ICD codes.

Data:  Table 2 displays rates of VTE associated with various sites of cancer.  Cancers with highest rates of VTE included
pancreas, 8.0%; odds ratio, 2.46 (2.34–2.58)
other abdominal (other than stomach, pancreas, colon, rectum, kidney), 6.6%; OR, 1.75 (1.67-1.83)
ovary, 5.6%; OR, 1.57 (1.48-1.66)
kidney, 5.6%; OR, 1.71 (1.62-1.80)
lung, 5.1%; OR, 1.31 (1.27-1.35)
brain, 4.7%; OR, 1.74 (1.65-1.84)

About Amy

Clinical Informationist at EUH Branch Library
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