In patients with obstructive sleep apnea (OSA), what is the risk for coronary disease?

Marin JM, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study.  Lancet. 2005;365(9464):1046-53.  Full-text

To compare the incidence of fatal and non-fatal cardiovascular events in simple snorers, patients with untreated obstructive sleep apnoea-hypopnoea, patients treated with CPAP, and healthy men

Prospective observational study that included 264 healthy men from the general population and 377 simple snorers, 403 with untreated mild-moderate obstructive sleep apnoea-hypopnoea, 235 with untreated severe disease, and 372 with the disease and treated with CPAP recruited from patients referred to a sleep clinic. CPAP was recommended for patients with 30+ episodes of apnoea or hypopnoea per hour of sleep and for patients with 5-29 with other factors (eg, severe daytime sleepiness, cardiac failure.) Patients were followed-up for at least once a year for average of 10 years.

Summary of data
Subjects with severe untreated OSA had a higher incidence of fatal and non-fatal (ie, non-fatal myocardial infarction, stroke, and acute coronary insufficiency) events than healthy subjects, as well as simple snorers, those with mild-moderate OSA, and those treated with CPAP. See
Table 2

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