“Most frequent symptoms are in (descending order):
gastroesophageal reflux with or without dysmotility
* “A negative antinuclear antibody test (by indirect immunofluorescence) makes the diagnosis of scleroderma very unlikely.
* The degree of skin involvement is highly variable. Many patients with limited scleroderma have only subtle cutaneous findings (eg, mild sclerodactyly).
* The current classification criteria do not include many patients with milder forms of scleroderma.
* Some patients may have overlapping clinical features with other systemic autoimmune rheumatic disorders such as polymyositis/dermatomyositis, Sjögren syndrome, systemic lupus erythematosus, and rheumatoid arthritis.”
In DynaMed Plus:
See article entitled “Systemic sclerosis”
For management of renal crisis, see section for renal symptoms within the medications section of the treatment section of the article entitled “Systemic sclerosis”
Updated 2/11/2016 ldt