What is the diagnostic value of various tests for pheochromocytoma?

Summary of selected likelihood ratios & sensitivity/specificity from the 2 studies

Lenders JW, et al. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA. 2002 Mar 20;287(11):1427-34.
PMID: 11903030
Cohort study of patients referred for testing — 214 confirmed pheochomocytoma & 644 confirmed negative — Compared plasma free metanephrines, plasma catecholamines, urinary catecholamines, urinary total and fractionated metanephrines, and urinary vanillylmandelic acid.

Unger N, et al. Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass. Eur J Endocrinol. 2006 Mar;154(3):409-17.
PMID: 16498054
Prospective study — 24 confirmed pheochromocytoma, 68 w/other types of adrenal masses, 16 w/essential hypertension & 42 healthy, normotensive volunteers –Compared plasma and urine epinephrine and norepinephrine levels as well as plasma and urinary metanephrine and normetanephrine levels

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About Amy

Clinical Informationist at EUH Branch Library
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